neurotrophic factor (R&D Systems)
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neurotrophic factor
Neurotrophic Factor, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 208 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+bdnf/Recombinant+Human+BDNF+Protein/pm42014405-313-31-34
Average 96 stars, based on 208 article reviews
Neurotrophic Factor, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 208 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+bdnf/Recombinant+Human+BDNF+Protein/pm42014405-313-31-34
Average 96 stars, based on 208 article reviews
neurotrophic factor - by Bioz Stars,
2026-09
96/100 stars
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Recombinant:Article Title: An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Article Snippet: 17504044), SHH (Sonic Hedgehog, 200 ng/ml, R&D), and CT (1 μM CT99021, Sigma). .. After 7 days of differentiation, SHH and CT were removed from media, and Article Title: Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity Article Snippet: In the second round of validation, using only the Novus antibody, we used the following samples: (1) 25 μg plasma protein mixed from 8 subjects from project 1, (2) 20 μg human platelet protein extract, (3) 20 μg human skeletal muscle protein, (4) 20 μg of mouse soleus protein, (5) 20 μg of mouse extensor digitorum longus (EDL) protein, (6) 35 μg protein from HeLa cell lysate (negative control), (7) 0.1 μg Mouse IgG (negative control), and (8) 1 ng recombinant pro-BDNF. .. Finally, we validated the Abcam #ab108319 Ab for the detection of mBDNF in human skeletal muscle using the following samples: (1) human skeletal muscle homogenate 40 μg protein; (2) human skeletal muscle homogenate 20 μg protein; (3) human type I fiber pool 25 μg protein; (4) human type II fiber pool 25 μg protein; (5) human plasma protein 15 μg of protein; (6) human plasma protein 30 μg of protein; (7) human platelet extract 4 μg protein; (8) human platelet extract 8 μg protein; (9) human platelet extract 12 μg protein; (10) HeLa cell lysate (Santa Cruz Biotechnology sc-2200) 35 μg protein, serving as a negative control lysate; (11) mouse IgG 0.1 μg, serving as a negative control; (12) Article Title: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy Article Snippet: .. Establishment and characterization of iPSCs from SBMA patients (SBMA1E12, SBMA2E16, SBMA3E10, and SBMA4E5 clones) and healthy controls (EKN3, TIGE9, YFE16, and YFE19 clones) were described elsewhere . iPSCs were differentiated into motor neurons through embryoid bodies (EBs) as previously described , , and dissociated EBs were plated onto dishes coated with growth factor reduced Matrigel (Corning, Corning, NY) at a density of 1 × 10 5 cells/cm 2 and cultured in motor neuron medium consisting of KBM Neural Stem Cell medium (Kohjin Bio, Saitama, Japan) or Media Hormone Mix (MHM) supplemented with 2% B27 supplement (Thermo Fisher Scientific), 1% non-essential amino acids (Thermo Fisher Scientific), 50 nM retinoic acid (Sigma-Aldrich), 500 nM purmorphamine (Calbiochem, Germany), 10 μM cyclic AMP (Sigma-Aldrich), 10 ng/mL Article Title: EGR1-mediated repression of HDAC2 regulates BDNF-dependent kindling development in a mouse model of pentylenetetrazol-induced epilepsy. Article Snippet: Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects millions of people worldwide.. Recent studies have reported altered expression of early growth response 1 (Egr1), an activityinducible immediate early gene, and histone deacetylase 2 (HDAC2), a regulator of gene transcription through the removal of acetyl groups from histone tails, in the hippocampus of epilepsy patients and animal models.. Here, we investigated the roles of EGR1 and HDAC2 in pentylenetetrazol (PTZ)-induced seizures in kindled mice. Article Title: EPHRIN-A1 and -A2 act as positive growth factors for developing spiral ganglion radial bundles. Article Snippet: During the formation of the auditory system in mammals, spiral ganglion neurons (SGNs) form ribbon-type synapses with hair cells in the cochlea to establish the first “sensorineural” component of sound transduction.. Ahead of synapse formation in the cochlea, the SGNs undergo migration and extension with developing Schwann and otic mesenchyme cells to form radial bundles, fasciculated groups of nerve fibers found between the SGN somata and hair cells.. Thus far, reports have shown that Eph/Ephrin signaling is important for the formation of radial bundles. Article Title: Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Aβ oligomer-induced long-term synaptic plasticity and memory impairment. Article Snippet: Expression of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus is impaired in Alzheimer's disease (AD).. However, CRTC1 related mechanisms associated with long-term synaptic plasticity impairment and cognitive decline in the onset of AD are unknown.. In this study, electrophysiological recordings indicated that lentivirus-mediated CRTC1 overexpression effectively ameliorates suppression of late-phase long-term potentiation (L-LTP) in rat hippocampal slices treated with oligomeric amyloid β(1–42) peptides (oAβ42) (200 nM). Article Title: BDNF-mediated regulation of GSK-3β and PSD95 phosphorylation in anti-depressive effects of Capsosiphon fulvescens glycoproteins against chronic alcohol exposure Article Snippet: Under aseptic conditions, an infusion guide cannula (22-gauge; Plastics One, Roanoke, VA, USA) was implanted using the following coordinates from the bregma: anterior-posterior, − 4.36 mm; dorsal–ventral, − 8.0 mm; and medial–lateral, 4.3 mm. .. After a 28-gauge dummy cannula was inserted to prevent the guide cannula from clogging, the rats were allowed to recover for 5 d. This dummy cannula was replaced with a 28-gauge internal cannula that protruded 0.5 mm beyond the guide cannula, and function-blocking anti-BDNF antibodies (1 μg/μL; Abcam) or Article Title: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy. Article Snippet: .. Establishment and characterization of iPSCs from SBMA patients (SBMA1E12, SBMA2E16, SBMA3E10, and SBMA4E5 clones) and healthy controls (EKN3, TIGE9, YFE16, and YFE19 clones) were described elsewhere16. iPSCs were differentiated into motor neurons through embryoid bodies (EBs) as previously described16,67, and dissociated EBs were plated onto dishes coated with growth factor reduced Matrigel (Corning, Corning, NY) at a density of 1 × 105 cells/cm2 and cultured in motor neuron medium consisting of KBM Neural Stem Cell medium (Kohjin Bio, Saitama, Japan) or Media Hormone Mix (MHM)68 supplemented with 2% B27 supplement (Thermo Fisher Scientific), 1% non-essential amino acids (Thermo Fisher Scientific), 50 nM retinoic acid (Sigma-Aldrich), 500 nM purmorphamine (Calbiochem, Germany), 10μM cyclic AMP (Sigma-Aldrich), 10 ng/mL Clinical Proteomics:Article Title: Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity Article Snippet: In the second round of validation, using only the Novus antibody, we used the following samples: (1) 25 μg plasma protein mixed from 8 subjects from project 1, (2) 20 μg human platelet protein extract, (3) 20 μg human skeletal muscle protein, (4) 20 μg of mouse soleus protein, (5) 20 μg of mouse extensor digitorum longus (EDL) protein, (6) 35 μg protein from HeLa cell lysate (negative control), (7) 0.1 μg Mouse IgG (negative control), and (8) 1 ng recombinant pro-BDNF. .. Finally, we validated the Abcam #ab108319 Ab for the detection of mBDNF in human skeletal muscle using the following samples: (1) human skeletal muscle homogenate 40 μg protein; (2) human skeletal muscle homogenate 20 μg protein; (3) human type I fiber pool 25 μg protein; (4) human type II fiber pool 25 μg protein; (5) human plasma protein 15 μg of protein; (6) human plasma protein 30 μg of protein; (7) human platelet extract 4 μg protein; (8) human platelet extract 8 μg protein; (9) human platelet extract 12 μg protein; (10) HeLa cell lysate (Santa Cruz Biotechnology sc-2200) 35 μg protein, serving as a negative control lysate; (11) mouse IgG 0.1 μg, serving as a negative control; (12) Negative Control:Article Title: Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity Article Snippet: In the second round of validation, using only the Novus antibody, we used the following samples: (1) 25 μg plasma protein mixed from 8 subjects from project 1, (2) 20 μg human platelet protein extract, (3) 20 μg human skeletal muscle protein, (4) 20 μg of mouse soleus protein, (5) 20 μg of mouse extensor digitorum longus (EDL) protein, (6) 35 μg protein from HeLa cell lysate (negative control), (7) 0.1 μg Mouse IgG (negative control), and (8) 1 ng recombinant pro-BDNF. .. Finally, we validated the Abcam #ab108319 Ab for the detection of mBDNF in human skeletal muscle using the following samples: (1) human skeletal muscle homogenate 40 μg protein; (2) human skeletal muscle homogenate 20 μg protein; (3) human type I fiber pool 25 μg protein; (4) human type II fiber pool 25 μg protein; (5) human plasma protein 15 μg of protein; (6) human plasma protein 30 μg of protein; (7) human platelet extract 4 μg protein; (8) human platelet extract 8 μg protein; (9) human platelet extract 12 μg protein; (10) HeLa cell lysate (Santa Cruz Biotechnology sc-2200) 35 μg protein, serving as a negative control lysate; (11) mouse IgG 0.1 μg, serving as a negative control; (12) Cell Culture:Article Title: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy Article Snippet: .. Establishment and characterization of iPSCs from SBMA patients (SBMA1E12, SBMA2E16, SBMA3E10, and SBMA4E5 clones) and healthy controls (EKN3, TIGE9, YFE16, and YFE19 clones) were described elsewhere . iPSCs were differentiated into motor neurons through embryoid bodies (EBs) as previously described , , and dissociated EBs were plated onto dishes coated with growth factor reduced Matrigel (Corning, Corning, NY) at a density of 1 × 10 5 cells/cm 2 and cultured in motor neuron medium consisting of KBM Neural Stem Cell medium (Kohjin Bio, Saitama, Japan) or Media Hormone Mix (MHM) supplemented with 2% B27 supplement (Thermo Fisher Scientific), 1% non-essential amino acids (Thermo Fisher Scientific), 50 nM retinoic acid (Sigma-Aldrich), 500 nM purmorphamine (Calbiochem, Germany), 10 μM cyclic AMP (Sigma-Aldrich), 10 ng/mL Article Title: Restoring early postnatal synaptic dysregulation rescues motor neuron degeneration in a mouse model of Spinal and Bulbar Muscular Atrophy. Article Snippet: .. Establishment and characterization of iPSCs from SBMA patients (SBMA1E12, SBMA2E16, SBMA3E10, and SBMA4E5 clones) and healthy controls (EKN3, TIGE9, YFE16, and YFE19 clones) were described elsewhere16. iPSCs were differentiated into motor neurons through embryoid bodies (EBs) as previously described16,67, and dissociated EBs were plated onto dishes coated with growth factor reduced Matrigel (Corning, Corning, NY) at a density of 1 × 105 cells/cm2 and cultured in motor neuron medium consisting of KBM Neural Stem Cell medium (Kohjin Bio, Saitama, Japan) or Media Hormone Mix (MHM)68 supplemented with 2% B27 supplement (Thermo Fisher Scientific), 1% non-essential amino acids (Thermo Fisher Scientific), 50 nM retinoic acid (Sigma-Aldrich), 500 nM purmorphamine (Calbiochem, Germany), 10μM cyclic AMP (Sigma-Aldrich), 10 ng/mL |
